Dual-Targeting Nanoprobe for Early Diagnosis of Pheochromocytoma Though Coinstantaneous Identification of Circulating Tumor Cells

نویسندگان

چکیده

Circulating tumor cells (CTCs) play a pivotal role in the early diagnosis of pheochromocytoma (PCC). Herein, we fabricated new dual-targeting nanoprobe for coinstantaneous identification rare PCC-CTCs from peripheral blood via targeting norepinephrine transporter (NET) and somatostatin receptor SSTR2 overexpressed on surface PCC cells. Meta-iodobenzylguanidine (MIBG) functionalized magnetic Fe3O4 octreotide (DOTA) decorated signal amplification Ag@SiO2 nanosphere were used to capture detect by binding NET SSTR2. The proposed sensor achieved good reproducibility high sensitivity monitoring PC12 concentration range 5 × 104 mL–1, with detection limits 2 cell/mL. This strategy opens approach simple, sensitive, rapid determination biomarkers, which shows great potential diagnosis, prognosis, therapeutic evaluation PCC.

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ژورنال

عنوان ژورنال: Analytical Chemistry

سال: 2021

ISSN: ['1520-6882', '0003-2700']

DOI: https://doi.org/10.1021/acs.analchem.1c01977